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KMID : 0043320230460110855
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Archives of Pharmacal Research
2023 Volume.46 No. 11 p.855 ~ p.881
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Targeting dysregulated lipid metabolism in the tumor microenvironment
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Kim Do?Hee
Song Na?Young
Yim Hyung-Shin
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Abstract
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The reprogramming of lipid metabolism and its association with oncogenic signaling pathways within the tumor microenvironment(TME) have emerged as signifi cant hallmarks of cancer. Lipid metabolism is defi ned as a complex set of molecularprocesses including lipid uptake, synthesis, transport, and degradation. The dysregulation of lipid metabolism is aff ected byenzymes and signaling molecules directly or indirectly involved in the lipid metabolic process. Regulation of lipid metabolizingenzymes has been shown to modulate cancer development and to avoid resistance to anticancer drugs in tumors andthe TME. Because of this, understanding the metabolic reprogramming associated with oncogenic progression is importantto develop strategies for cancer treatment. Recent advances provide insight into fundamental mechanisms and the connectionsbetween altered lipid metabolism and tumorigenesis. In this review, we explore alterations to lipid metabolism andthe pivotal factors driving lipid metabolic reprogramming, which exacerbate cancer progression. We also shed light on thelatest insights and current therapeutic approaches based on small molecular inhibitors and phytochemicals targeting lipidmetabolism for cancer treatment. Further investigations are worthwhile to fully understand the underlying mechanisms andthe correlation between altered lipid metabolism and carcinogenesis.
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KEYWORD
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Tumor microenvironment, Lipid uptake, Lipolysis, Lipogenesis, Cholesterol transport, Phytochemical
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